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The inhibition of Akt, calcineurin A, ERK1/2 and TGF-1 signaling pathways in the heart may be the mechanism of Rd to improve cardiac dysfunction and remodeling induced by pressure load (Zhang et al., 2019)

Alharbi A, Al-Sowayan NS

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On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level