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The damaging effect of ROS is manifested by DNA damage and genomic instability, promoting cancer incidence

To this end, we isolated primary hepatocytes from Peli3 +/+ WT and Peli3 / KO mice and subsequently treated them with 20 mM APAP for 2 h

This inflammation leads to structural and architectural changes in the airways of asthmatic patients including collagen and fibronectin deposition, wall thickening, subepithelial fibrosis and hypertrophy, goblet and airway smooth muscle cell hyperplasia, and angiogenesis, all of which collectively contribute to the phenomenon known as airway remodeling [25]