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2-Deoxyglucose (2DG), a glucose analog, is phosphorylated by HK2 and thus form a non-metabolizable substance, 2-DG-6-phosphate after entering cancer cells, which interferes with glycolysis (93)

Concurrently, GLPs suppress innate immune hyperactivation by inhibiting both the NLRP3 inflammasome assembly and the TLR4MyD88NF-B signaling cascade, thereby significantly downregulating key pro-inflammatory mediators such as IL-1, IL-6, and TNF- (Liu J

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