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In response to oxidative stress or protein misfolding, the ER activates the unfolded protein response (UPR) to restore homeostasis

As these research directions continue to deepen, GPx4-targeted therapies will bring breakthroughs in the treatment of a variety of diseases, which will not only provide new treatment options for cancer patients, but also is expected to open up new avenues in the fields of neuroprotection and cardiovascular disease prevention, and to promote the development of individualized medicine to a higher level

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