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It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria

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For roots, the first two principal components explained 64.8% of the total variance (Dim1 = 43.3%

TL, TM, and OM were measured to assess and compare apoptotic DNA damage between groups (Table 2)