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At 24 weeks, high-risk subjects treated with PGZ had highly significant absolute reduction in FAST score compared to placebo (-0.47 vs -0.17 respectively p=0.0006) with 63% shifting from high to low-risk category compared to only a 15% shift for placebo

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While enzymatic kits measuring intracellular GSH and glutathione disulfide (GSSG) are commonly employed in cell line development workflows, comprehensive LC-MS-based methods enhance redox analysis to include the amino acid components of GSH (cysteine, glycine, and glutamate), the GSH/GSSG ratio, and other markers and mitigators of ROS, both inside and outside the cell