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325,326 In HD, HSP27 exerts neuroprotective effects by suppressing polyglutamine toxicity and lowering ROS levels, thereby slowing neurodegenerative progression

Glutathione conjugation plays a significant role in detoxifying reactive electrophilic compounds

Concurrently, changes in -Syn secondary structure and fibril morphology induced by copper/iron ions enhance its aggregation and cellular toxicity (175)