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Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

Why it matters: REDEFINE 3 will be key for regulatory and clinical adoption of CagriSema

3), including H-bonds with the backbone of S129 ECD , and hydrophobic interactions with D77 ECD , G78 ECD , W79 ECD , Y131 ECD and W128 ECD , consistent with interactions also formed by Pro32 of sCT

Its Phase 3 weight-loss figures (in the low-to-mid 20% range) and its late-2025 FDA filing belong to the combination product, not to standalone cagrilintide, which remains at the Phase 2 stage with a peer-reviewed monotherapy result of about 10.8% at 26 weeks