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doi: 10.1016/j.ejphar.2021.173974

The core difference is receptor targeting

Stop the plan and see your provider if you develop chest tightness, severe dizziness, swelling of the lips or face, or trouble breathing

Studies with PYY agonists administered intravenously have shown reduction in food intake with increased satiety [92, 93], however, a nasal PYY agonist showed minimal efficacy with poor tolerability [94]