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Shakeri H, Lemmens K, Gevaert AB, De Meyer GRY, Segers VFM

Curr Opin Drug Discov Devel 10:533539 Doig AJ, Derreumaux P (2015) Inhibition of protein aggregation and amyloid formation by small molecules

In contrast, a study identified phosphorylation of BID by JNK at T59 prevents caspase 8 cleavage, but despite the lack of cleavage this drives apoptosis (Prakasam et al., 2014)

In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier