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While research is still ongoing, most findings thus far are based on animal studies rather than human trials (338)

3.1 Methods of H 2 application in agriculture Exposure and treatment of plants with H 2 can be carried out in a variety of methods, from H 2 -producing bacteria (Maimaiti et al., 2007), using it as a gas, having water or aqueous feed enriched with H 2 (hydrogen-rich water (HRW)), or creation of nanobubbles (hydrogen nanobubble water (HNW)), as outlined in Table 2

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It has been also reported that selenium may regulate the inflammatory response by reducing the release of tumor necrosis factor (TNF) and cyclooxygenase (COX2), as well as the activation of nuclear factor B (NF-B) which is one of the transcriptional factors involved in the immune and pro-inflammatory response