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Hydrogen peroxide and superoxide radical anions are the main intracellular ROS, which are predominantly generated in mitochondria

Because the disulfide bridge (a cyclic disulfide) can undergo redox reactions, during the reactions catalyzed by the pyruvate dehydrogenase complex it is first reduced to dihydrolipoamide, a dithiol (the reduced form of the prosthetic group), and then reoxidized to the cyclic form

Probiotic-fermented pueraria lobata (Willd.) ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota