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A 2016 study published in Nature Medicine demonstrated that MOTS-c administration improved insulin sensitivity and reduced diet-induced obesity in mouse models, even when started after metabolic dysfunction was already established

doi: 10.1016/j.nbd.2013.08.003, 91 MiyazakiI.MurakamiS.TorigoeN.KitamuraY.AsanumaM

Strengths of this research include a diverse geographic recruitment of participants and a sample which includes members from multiple military branches and a large proportion of female participants, which is uncommon in veteran research

This age-related NAD+ depletion impairs mitochondrial energy production, reduces SIRT1 activity, compromises DNA repair mechanisms, and accelerates cellular senescence