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Vitamin B12 for cancer patients is something you should speak with your doctor about, but some studies show it may reduce pain

The MHRA has issued a Drug Safety Update advising that patients on long-term metformin treatment should be monitored for vitamin B12 deficiency

For example, to help ensure that participants attended scheduled visits, trial protocols for SCALE phase 3a trials of liraglutide 3.0 mg for weight loss included reminders at each visit to book the next appointment [26, 27]