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(1999) 51 Suppl 3:1048

The sequences of the primers used in this study are shown in Table S2

CD4 + , CD8 + , and T cells drive inflammation and activate HSCs, which in turn regulate T cell differentiation and proliferation

This translational gap motivates an engineering solution: polysaccharide-based nanomedicines that exploit the inflammatory microenvironment (pH, ROS, bacterial glycosidases, receptor overexpression) to achieve spatiotemporally controlled delivery and thereby amplify the very mechanisms delineated above