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10.1371/journal.pmed.1003100

466 There is a robust association between a spermidine-rich nutritional diet and improved survival in humans (NCT03378843)

All subjects from cohorts 1 through 3, and 1 subject from cohort 4 were evaluated at a variety of time points

The enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) attaches a methyl group from methylcobalamin (b12) to homocysteine resulting in methionine