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DOI: 10.3390/jcm9093019 64

Sea buckthorn extracts have also been shown to reduce serum and liver triglyceride concentrations by nearly 50% in high-fat diet-induced obese mice, with these effects due to inhibition of peroxisome proliferator-activated receptor gamma (PPAR), activating adenosine monophosphate (AMP)-activated protein kinase (AMPK) and Akt, as well as improved insulin signaling