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To identify the selective cargos of V-ATPase-dependent autophagy, we tagged different organellar proteins with GFP at the C-terminal end and performed GFP-processing assays: We found a clear increase in the vacuolar degradation of ribosomal proteins Rps6A and Rpl10, indicating the induction of ribophagy (Fig

In this study, B12 levels were 244 pmol/l or more in all patients at baseline, but in those who improved, B12 levels almost quadrupled, whilst in non-responders B12 levels went up by only 50%