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Fluorescent probes and mass spectrometry-based methods to quantify thiols in biological systems

For instance, although MMP-1 efficiently degrades collagen, it is predominantly expressed in AECs during IPF, where it promotes epithelial repair and inhibits apoptosiseffects suppressed by the dominant profibrotic mediator TGF- ( 2 (PGE 2 )-mediated pathways and preserving non-fibrotic lung regions ( Collectively, MMPs drive IPF by activating TGF-, altering ECM biomechanics, and sustaining myofibroblast survival, making them therapeutic targets