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Description

CD38, a multifunctional protein that acts as both receptor and ectoenzyme, is overexpressed at all stages of myeloma

Cognitive Support Higher NAD levels activate sirtuins 10 (SIRT1, SIRT3), which protect brain cells by reducing oxidative stress, supporting DNA repair, and improving mitochondrial health

They secrete IL-1, basic fibroblast growth factor, and VEGF, and regulate Ca 2+ mobilization through CD38-mediated cADPR, which is conducive to TMM activation, angiogenesis, and immunosuppression ( The Role of Targeted CD38 (Therapy) in Diseases The Role of an Anti-CD38 Monoclonal Antibody (mAb)and Its Synergy in the Treatment of Multiple Myeloma Daratumumab is a human specific IgG1 anti-CD38 antibody, which has been approved as a single drug or combined regimen for the treatment of recurrent/refractory multiple myeloma