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Zhuo and colleagues formulated tacrolimus-loaded chitosan nanoparticles decorated with hyaluronic acid (HA) and demonstrated that HA coating improved dermal targeting and resulted in superior anti-dermatitis efficacy [66]

In contrast, topoisomerase I inhibitors (e.g., DXd, SN-38) have emerged as a highly successful class of DNA-damaging payloads, offering a favorable balance of high potency and manageable safety profiles, as evidenced by the success of ADCs like trastuzumab deruxtecan (T-DXd) [48]

albicans and Candida glabrata (the current classification has been updated to Nakaseomyces glabratus 71 ) in bile duct samples from PSC patients 72