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The catalytic a and a domains are sufficient for protein oxidation, but the b and b domains are necessary for isomerization (Tsunoda et al., 2014), and further work identified ER oxidoreductase 1-alpha (ERO1), ER-localized peroxiredoxin 4 (PRDX4), glutathione peroxidase 7 (GPx7), glutathione peroxidase 8 (GPx8), and Vitamin K epoxide reductase as alternative mechanisms for PDI oxidation (Cabibbo et al., 2000
Canaries in a coalmine Toxic load increases over time and the longer we live in our modern world where chemicals are ubiquitous
Clinical Features NNJ related to G6PD deficiency is very rarely present at birth
