doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois
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The problem with PCOS went far beyond semantics: It implied the ovaries were the problem leading to decades of care siloed in gynecology when the condition actually involves the endocrine, metabolic, cardiovascular, dermatologic, and psychological systems It delayed diagnosis women without visible polycystic ovaries on ultrasound were told they didnt have PCOS, even when they had every other symptom It fragmented care patients bounced between gynecologists, endocrinologists, dermatologists, and psychiatrists because no single specialty owned a condition named after ovarian cysts It created stigma the word syndrome paired with polycystic made women feel like something was fundamentally wrong with their reproductive organs, when the reality is a whole-body hormonal and metabolic condition It limited research funding framing PCOS as a gynecological condition reduced its priority in metabolic, cardiovascular, and endocrine research The new name Polyendocrine Metabolic Ovarian Syndrome (PMOS) directly addresses these failures by: Polyendocrine acknowledging that multiple hormonal systems are involved (insulin, androgens, cortisol, thyroid, and more) Metabolic recognizing the central role of insulin resistance, metabolic dysfunction, and cardiovascular risk Ovarian maintaining the reproductive connection without reducing the condition to cysts Removing polycystic eliminating the misleading reference to cysts that dont exist as traditionally understood What PMOS Actually Is: A Multisystem Condition PMOS affects approximately 1 in 8 women more than 170 million worldwide
Lewis (18751946), and Michael Kasha (19202013) to emphasize the contribution of other researchers to the development of this concept
