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This process is key to DNA synthesis and methylation

doi: 10.1074/jbc.M307600200 81 ItoKIkedaSKojimaNMiuraMShimizu-SaitoKYamaguchiIet al

10.1016/j.phrs.2020.104784 162 WilliamsP

Multiple causes, multiple targets AD as an heterogeneous disease The amyloid hypothesis as the essential cause of neuronal loss and brain atrophy is a matter of discussion mainly because removal or reduction of amyloid plaques by immunological treatments display no significant effect on clinical symptoms of AD [39, 140]