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While the inhibition of MAO-A in the brain is necessary for an antidepressant effect, inhibition of both MAO-A and MAO-B provides a greater increase in serotonin, norepinephrine, and dopamine than inhibition of either MAOI isomer alone (Figure 1A and B).27,29 Theoretically, inhibition of both MAO-A and MAO-B can lead to greater increases of each neurotransmitter compared with inhibition of either isoenzyme alone

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