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Nat Immunol 22:11271139 Xu C et al (2021) The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

HIF- proline hydroxylation Jaakkola and colleagues [88] recently indicated that the interaction between human pVHL and a specific domain of the HIF-1 subunit is regulated through hydroxylation of a proline residue (HIF-1 Pro564) by an enzyme termed by the authors HIF- prolyl-hydroxylase (HIF-PH)