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Nat Rev Neurol 11(11):625636

Side Effects and Reactions Most injections have minimal side effects, but some individuals may experience redness or swelling at the injection site

This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state

Symptoms of low blood pressure include: dizziness or confusion nausea lightheadedness that may result in fainting, especially after standing up quickly general fatigue that may get worse throughout the day being unable to catch the breath or taking shallow, rapid breaths thirst, even after drinking cold, pale, or clammy skin vision problems, such as blurred vision or double vision depression Any person who experiences troublesome symptoms such as these needs to report them to a healthcare professional