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Initially, they devised a macrocyclisation method that involves lysine residues in an unprotected peptide, using an excess of formaldehyde with the assistance of nearby tyrosine or arginine residues in close proximity (referred to as KaY/KaR stapling)

Across all storage conditions, the addition of 1000 g/mL EDTA most significantly reduced the formation of diNAC in solution under the storage conditions tested

Elevated urinary KIM-1 levels in SLE patients suggest its utility as a non-invasive biomarker for renal involvement and progression of LN (350)