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* Correspondence: Ioannis Georgiou [email protected] Specialty Section: This article was submitted to Assisted Reproduction, a section of the journal Frontiers in Reproductive Health Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

UCDs occur in ~1 in 35,000 births, among which OTC deficiency is the most common, with an incidence of 1 in 56,500 births 4

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