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In addition, the possibility to manipulate SLC25A39 and/or to regulate the amount of GSH that enters mitochondria also offers the opportunity to study the importance of mitochondrial GSH in more detail, especially in mitochondria-rich tissues like liver or kidney

In this study, we showed that RSL3 induces autophagy through the suppression of mTOR signaling

In addition, spatiotemporal ribonucleic acid-sequencing (RNA-seq) analyses in the mouse brain (N = 15 ROIs, seven age groups) further demonstrate region-specific (a) expression of Gss , Gclc and Gclm , three genes encoding enzymes involved in GSH synthesis, at a single time point, as well as (b) change in the expression level of these genes with age, with examples that include age-related increases of Gclc and Gclm in the hypothalamus and medulla, respectively (Hahn et al., 2022, Spatiotemporal Brain Map, 000)

In recent years, ferulic acid derivatives have been widely investigated