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We additionally hypothesized that held-out metabolites that the model failed to ever generate would tend to occupy more distinct regions of chemical space with few similar structures in the training set

Similar to our results, Edin et al

Wright CJ, Rentschler KM, Wagner NT, Lewis AM, Beggiato S, Pocivavsek A (2021) Time of day-dependent alterations in hippocampal kynurenic acid, glutamate, and GABA in adult rats exposed to elevated kynurenic acid during neurodevelopment