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10.1016/j.tibs.2014.06.005 2

Endogenous ROS Production The main endogenous sites of cellular redox-reactive species generation-including ROS and reactive nitrogen species (RNS) comprise mitochondrial electron transport chain (ETC), endoplasmic reticulum (ER), peroxisomes, membrane-bound NADPH oxidase (NOX) isoforms 15, dual oxidases (Duox) 1 and 2 complexes, and nitric oxide synthases isoforms 15 (NOS13)