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This interaction triggers endocytic uptake, followed by intracellular trafficking and exocytosis at the abluminal membrane into the brain parenchyma

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Nature , 432 (7016), 466472.

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Retarutide inhibited human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775nM, respectively

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