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The vitamin-C derivatives also easily penetrate the skin because the skin has a lipid barrier (think: oil dissolves oil), so theres not as much resistance to the ingredients as something water soluble (like L-ascorbic acid)

10.1126/sciadv.abc7031 98

We estimated the total annual cost to be $4,857,458.20 ($1,598.90 3,038 IPPS hospitals) (Table 158)

Petersburg Institute of Bioregulation and Gerontology, Epithalon was synthesized based on the amino acid composition of epithalamin, a naturally occurring polypeptide complex extracted from the bovine pineal gland