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We are finalizing modifications to our proposed code descriptor for Level 1 APCM services to indicate the presence of one or fewer chronic conditions that are expected to last at least 12 months or until the patient's death and or that place them at significant risk of death, acute exacerbation and or decompensation, or functional decline. We point out to commenters that we had already included this definition of chronic condition for Level 2 and Level 3 APCM services

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Semi-automated freeze-substitution was performed using an AFS2 device (Leica) equipped with customized aluminum sapphire disc revolvers and samples were subsequently embedded in epoxy resin according to a previously published protocol 73