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Methods Animal preparation and experimental groups All animal experiments complied with the ARRIVE guidelines

After co-transfection of miRNA and luciferase reporter plasmids, luciferase activity in cells was detected by the microplate reader

According to the authors, other reported complications of coffee enemas include: thermal burns from heated coffee enemas stricture, which is an area of narrowing within the intestines bowel perforation Considerations Before considering a coffee enema, people should familiarize themselves with the potential risks of the procedure