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Our model also provides crucial insights for the design or optimization of artificial glutaredoxins, transition-state inhibitors and glutaredoxin-coupled redox sensors

However, certain cell types, such as those in the hair follicles, gastrointestinal tract, and oral mucosa, divide rapidly under normal conditions, thus begetting the common side effects associated with chemotherapy (Mukherjee 2010

In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)

Clinical studies have shown that at the time of diagnosis, -cell mass and function are significantly reduced in patients with T2DM [27]