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Sex and estrous cycle effects on anxiety- and depression-related phenotypes in a two-hit developmental stress model

(University of Washington Seattle, 1993)

Lactate secreted by CRC cells promotes the polarization of TAMs toward an M2-like immunosuppressive phenotype, impairs CD8 T cell function, and reduces the efficacy of ICIs [126]

In addition, studies suggest roles in angiogenesis, peripheral nerve outgrowth, antioxidant defense, and modulation of inflammatory activity, including in models of chronic pulmonary injury[2]