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Similar results were observed in off-road cyclists, where both short-term (6 d) and long-term (21 d) sodium phosphate supplementation (50 mg/kg) significantly increased VO 2max and maximal aerobic power, with no significant changes in 2,3-DPG levels (28)

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Over time, a substantial proportion of patients develop a progressive phase, typically 10 to 15 years after disease onset, characterized by gradual accumulation of disability and ongoing neurodegeneration that becomes less directly associated with the acute inflammatory activity [104]

Some treatments can take up to a year before any benefit is seen