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10.7759/cureus.70435 122 NishidaY.KamataniN.MiyamotoT

32, 49464959 10.1128/MCB.00761-12 [DOI] [PMC free article] [PubMed] [Google Scholar] 99.Karlsson, H.K.R., Zierath, J.R., Kane, S., Krook, A., Lienhard, G.E

Cell 180, 688702.e13

In contrast, 12/15-LOX, found in endothelial cells, VSMCs, macrophages, and platelets, oxidizes arachidonic acid to 12-HETE and 15-HETE, leading to LDL oxidation, foam cell formation, and endothelial dysfunction