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Based on the current evidence, we propose that the iron-overloaded, ROS-prone milieu of EMS renders EESCs susceptible to Erastin-triggered, multi-pathway regulated cell death that integrates ferroptosis with necroptotic and pyroptotic signaling, while ferritin handling and mitophagy act as key modulators of susceptibility

Peptides are not only found in the body, but they are also naturally occurring in certain foods

An urgent need for rigorous, well-designed clinical trials and mechanistic studies to validate traditional claims, elucidate mechanisms of action, standardize treatments, and integrate these valuable traditional medical systems into evidence-based HACE management exists

Many of these unknown metabolites, particularly lipids that remain largely unstudied, may likely have interesting biological and pharmacological properties, which could facilitate the development of novel diagnostic and therapeutic products