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Conversely, MAT2A and MAT2B , which are normally expressed only by non-parenchymal cells of the liver and extrahepatic tissues, are induced in HCC[14,42,43]

TMZ is an FDA-approved DNA alkylating agent, and when combined with RT, it has shown to increase OS in patients with GBM

Though the exact mechanism has not been elucidated in these paradigms, these results suggest that MCTs play a role in the development of AD and that targeting MCTs may provide an avenue for the development of novel therapies