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Both compounds produce large body-weight reductions in obesity trials, and both are once-weekly subcutaneous injections dominated by gastrointestinal side effects

By identifying the specific region of growth hormone responsible for lipolytic activity (amino acids 176-191) and isolating this fragment, scientists created a targeted intervention with improved safety profile, fewer contraindications, reduced side effects, and simpler monitoring requirements compared to full growth hormone

In one study, 18 38 patients with vitamin B 12 deficiency were randomized to receive oral or parenteral therapy