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Among them, the free radical theory of aging proposed by Harman (1956) and further developed by several authors (Harman, 1956, 1972

Dig Dis Sci 67(12):53825391

Biochim Biophys Acta Mol Basis Dis 1869:166798

A number of drugs targeting these potential therapeutic points are in clinical trials or in development, offering new hope for ALS drug development and the alleviation and cure of the disease