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examined the effects of a dietary supplement called TOSLA with collagen, vitamin C, and hyaluronic acid (HA) on skin density, texture, and other parameters in a randomized, double-blind, placebo-controlled trial over 16 weeks in Slovenia [53]

Lancet 2 , 2324 (1968)

Comorbidities present in pillar pain patients included hypertension (48%), hypothyroidism (30%), rheumatoid arthritis (26%), diabetes mellitus (22%), fibromyalgia (9%), and vitamin deficiencies (9%), with no cases of chronic kidney disease in this sample