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Numerous studies indicate that phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway plays a critical role in cancer progression, making it a promising target for screening natural therapeutic candidates (Ong et al

Furthermore, supplementation with LC has a positive impact on numerous essential pathways involved in pathological skeletal muscle loss, which might explain at least some of the anti-catabolic benefits and improvements in fatigue-related metrics seen in chronic illness people who received it (Montesano et al., 2015, Ringseis et al., 2013)

*Correspondence: Barbara Falquetto, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

91 : 743745 Stahnke K, Fulda S, Friesen C, Strauss G and Debatin K-M (2001) Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy