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Comorbid patients have significantly elevated plasma kynurenine/tryptophan ratios, positively correlated with both constipation severity and depression scores (Myint and Kim, 2014)

proposed an indirect anticancer effect of venetoclax with the aid of dendritic cells (DCs) in vivo, depicted as the imgration and antigen presentation capacity of conventional type-1 DCs being potentiated by the activation of the cGAS/STING pathway and the subsequent classical type-1 interferon pathway when BCL2 is genetically or pharmacollogically inhibited, which eventually improves the immunosurveillance capacity of T cells and enhances ICI therapeutic efficacy

Moreover, as effective antioxidants, both acids can break glycation-oxidation vicious cycle that leads to AGE formation

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