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Ofwats chief executive, David Black, said of the Thames business plan: Costs were poorly justified, service levels were unsatisfactory and so that makes our job more challenging. He said the response to Thames had been fair and that it was up to Thames to convince investors of its turnaround as it attempts to raise fresh funds

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Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens