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Hoffman RL et al

3.2 GSH consumption and hydroxyl radical (OH) production GSH overexpressed in tumor cells can reduce Cu 2+ in Cu/ZIF8 to Cu + , which acts as a potent Fenton-like reagent capable of generating abundant OH when combined with H 2 O 2

HJM-561 (20, 40 mg/kg, p.o., once a day for 18 consecutive days) dose-dependently inhibits tumor growth in the human xenograft tumor (PDX) model, with a TGI of 67% at a dose of 40 mg/kg, and there is no significant change in mouse body weight [1]