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The LD control group was particularly distinct from the other groups in the unweighted UniFrac and BrayCurtis dissimilarity analyses plots, suggesting that animals exposed to the same diet at an early age in life diet develop similar microbiome profiles that persist even after an acute change in diet

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The peer-reviewed literature is also concentrated within a single research group (Watowich lab, University of Texas at Austin) and its industry partner Ridgeline Therapeutics, with limited independent replication to date

Therapeutic potential: Provides a model to study mechanisms that could inform future obesity and metabolic disorder interventions